Variceal Bleeding in Patients with Initation of Sofosbuvir and Ribavirin – Case Reports
Keywords:
Variceal bleeding, Sofosdbuvir, Ribavirin, Heptitis C, Nucleoside analogue, AntiviralAbstract
Abstract: Sofosbuvir is an oral nucleoside analogue and potent inhibitor of the Hepatitis C virus (HCV) RNA polymerase that is used in combination with other antiviral agents to treat chronic Hepatitis C Nevertheless, and for unknown reasons, successful antiviral therapy of Hepatitis C with Sofosbuvir and other direct acting agents in patients with cirrhosis is occasionally complicated by hepatic decompensation. Here we describe 2 case report of upper gi bleed at initial days of treatment with Sofosbuvir and Ribavirin.
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