Paradigm of Bone Marrow Metastasis in Retinoblastoma

Abstract

Abstract: Introduction: Retinoblastoma is most common pediatric ocular malignancy. Majority of patients presented with  unilateral disease. Infiltration to other organs is common with bone marrow being one of the most common organ involved.
Methodology: This study was conducted at Pakistan Institute of Medical Sciences Islamabad for a period of one year. A total of 47 known patients of retinoblastoma were included in study. All patients underwent bone marrow biopsy for evaluation of infiltration. Results: Out of 47 patients, 32 (68.1%) were male and 15 (31.9%) were female (ratio 2.13:1). 37 (78.7%) patients were unilateral and 10 (21.3%) were bilateral. Bone marrow infiltration was present in 14 (29.78%) cases. Conclusion: Bone marrow is among most common sites of involvement in patients with bone marrow biopsy. Distant metastatic involvement has great impact on treatment and overall survival of patients.