National Journal of Health Sciences <p>National Journal of Health Sciences (NJHS) aims to provide a platform that will construct substantial and reliable involvement of the scientific community; NJHS will publish scholarly articles as Open Access related to broad spectrum of research disciplines. NJHS offers a well-organized handling system that will provide the users speed and convenience in publications. Moreover, we will ensure publication of high quality manuscripts via efficient peer review process.</p> <p>The manuscripts that will be published can be accessed easily and free of cost. This will benefit not only the author(s) but readers as well. We are dedicated in the progression of science through widest probable propagation of trustworthy information, and will facilitate researchers that are one of our priorities. It will provide huge amount of free access of the content to scholars and researchers in the field of health sciences. Manuscripts that are clinically relevant will be made publicly available of each issue.</p> en-US (Mr. Muhammad Akif Ali Atif) (Ms. Maria Baig) Tue, 30 Mar 2021 07:34:27 +0000 OJS 60 Internal Root Resorption : A Review <p><strong>Abstract: </strong>Internal resorption is an asymptomatic condition in teeth seen with past history of injury. In the crown it has a clinical observation of pink mark. It is diagnosed by chance on an x-ray examination. Primal detection and resorption treatment improves prognosis of the condition. Resorption can be broadly classified into normal physiological or pathological process associated with extensive damage to hard structures of tooth such as dentin, cementum and bone. Proper diagnosis of resorption and differentiation of resorption from internal and external resorption by radiographic presentation and the correct diagnosis and treatment planning improves the prognosis of the condition. Untreated cases will cause loss or early exfoliation of the afflicted tooth [1].</p> Syeda Asiya Butool, Nitin Kararia, Shyam Aggrawal, Rachit Mathur, Manas Bajpai, Ankit Sharma Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 A Bibliometric Analysis of Global COVID-19 Research <p><strong>Abstract: Background: </strong>Coronavirus disease 2019 (COVID-19) has influenced all continents, prompting extraordinary efforts on worldwide research and publications to alleviate the crisis.</p> <p><strong>Methods: </strong>We conducted a bibliometric review using Scopus to assess its impact on global scientific production. We searched for the following terms in titles, abstracts, and keywords to identify relevant literature published until 9th January 2021: 2019 novel coronavirus, 2019-nCoV, SARS-CoV-2, COVID-19, coronavirus disease-19, coronavirus disease 2019.</p> Shaheer Ahmed, Usama Waqar, Kantesh Kumar Lohana, Daniyal Ali Khan Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Aldosterone: Implications in Diabetic Nephropathy <p><strong>Abstract: Objective: </strong>The focus of this review is to summarize the recent advancement to understand the molecular pathogenesis of diabetic nephropathy (DN). Also, to highlight the role of abnormal aldosterone secretion on the development and progression of diabetic nephropathy.</p> <p><strong>Background: </strong>Diabetic Nephropathy (DN) is a progressive disease of nephron due to slow progressive failure of kidney tubule to perform its filtration process. It is often associated with proteinuria and glomerular stiffening which eventually leads to low glomerular filtration rate, finally succumbs the patient toward the end stage of kidney disease. The abnormal level of aldosterone in diabetes mellitus is a fatal combination to combat because of progressive development of diabetic nephropathy.</p> <p><strong>Methods: </strong>We reviewed the literatures for implications of aldosterone in diabetic nephropathy. The literatures that were related to different aspects of diabetic nephropathy in relation to aldosterone were analyzed and summarized in this review article.</p> Fasiha Abdul Rehman, Zaid Abdul Razzak, Syed Saad Hussain Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Oral Spindle Cell Carcinoma –Diagnosis Based on Immunohistochemical Interpretation <p><strong>Abstract: </strong>Spindle Cell Carcinoma (SpCC) is a biphasic tumor. They are proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. It is a rare tumor which is infrequently observed in head, neck and in the aerodigestive tract. The tumor is aggressive and shows high frequency of recurrence and metastasis. It is an aggressive variant of squamous cell carcinoma which resembles a true sarcoma. It is a proliferation of spindle cells and squamous cells. For confirmation of diagnosis, immunohistochemistry is used. A Rare case of spindle cell squamous cell carcinoma in a 61 years old male in the tongue. The patient reported of rapidly growing lesion from six months with pain severe pain, dysphagia and difficulty in swallowing patient had history of chewing tobacco from past 35 years.</p> Syeda Asiya Butool, Ankit Natani, Betina Chandolia, Manas Bajpai Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Massive Proteinuria which Rapidly Resolved after Discontinuation of Regorafenib <p><strong>Abstract: </strong>Regorafenib is treatment option of cancers. It is associated with several adverse effects, including proteinuria. We report a massive proteinuria associated with regorafenib which resolved quickly after discontinuation of the drug. A 63 year old male presented with diarrhea and bilateral swallowing of legs. In urinanalysis, 18.5 g/day of proteinuria was detected. All symptoms, including proteinuria, resolved after discontinuation of regorafenib. Despite cessation of regorafenib treatment is advised in case of proteinuria, we suggest that regorafenib associated proteinuria could be rapidly resolved after discontinuation of the drug.</p> Mehmet Zahid Kocak, Gulali Aktas, Satilmis Bilgin, Tuba Taslamacioglu Duman, Ozge Kurtkulagi, Burcin Meryem Atak, Irem Emir Ozcil, Haluk Savli Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Iatrogenic Venous Compression Syndrome due to Surgical Lumbar Hardware <p><strong>Abstract: Background: </strong>The Iliac vein compression syndrome (IVCS) is most commonly due to May-Thurner variant, an anatomic variant where in the right common iliac artery overlies the left common iliac vein and compresses it against the lumbar spine. The compression of the common venous outflow tract of the left lower extremity may cause discomfort, swelling, or deep vein thrombosis in the iliofemoral veins. The role of the pelvic surgery particularly the lumbar hardware in the development of symptomatic Venous compression syndrome in patients with May-Thurner syndrome is not well understood. The incidence is presumably very low. Herein, we present six patients who developed IVCS after Lumbar hardware.</p> <p><strong>Method: </strong>The cases were diagnosed between Nov. 2016 to Oct. 2019 in the Outpatient Cath Lab of McKinney, TX. The patient’s medical records were retrospectively analyzed looking for risk factors, clinical features, venogram findings, and post venogram. The evaluation of each case was described, and common trends were later presented in a cross-case analysis.</p> Muhammad Akram Khan, Zahoor Khan, Abeera Azam Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Cord Compression from Bony Metastasis: An Important Quality of Life Issue which can be Resolved by a Spinal MDT Tumor Board <p>Cancer prevalence is increasing over the past few decades. Spinal osseous metastasis is one of the most common sites of secondary neoplastic disease among cancer patients [1]. Spinal malignancies can broadly be classified into primary spinal cancers and secondary spinal metastasis. Metastatic spinal cancers are more common than primary malignancy of the spine. Metastatic spinal cancers are further subdivided into two parts based on the involvement of the dura mater; metastasis external to dura mater can be termed as metastatic epidural spinal cancers (MESC); metastasis inside the dura mater is called metastatic intradural spinal cancers (MISC) [2]. Bony involvements of vertebrae are common at the presentation of MESC while the involvement of the spinal cord and meninges is a prominent feature of MISC. However, the clinical presentation is quite overlapping and timely-decision making is quite challenging in several cases. Several grading systems have been developed to assess the severity of spinal cancers [3-6]. Such ambiguities require a need for teamwork between different specialties to decide the management plan for better patient care. Multidisciplinary Tumor Boards (MDT) are the practical venue where different specialists are present for the discussion [7].</p> Sheikh Muhammad Ebad Ali, Badaruddin Sahito, Muhammad Amin Chinoy, Ahmed Nadeem Abbasi, Adil Khatri Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Obstructive Sleep Apnea in General Surgery Patients: Is Screening Required Preoperatively? <p><strong>Abstract: Aim: </strong>To screen cases who are at high risk and low risk for obstructive sleep apnea in general surgery patients.</p> <p><strong>Materials &amp; Methods: </strong>It is a cross-sectional study. It was done in Liaquat National Hospital from January 2019 to June 2019. After institutional approval, 335 patients were included in this study, who presented to general surgery OPD. STOP-BANG questionnaire was used to screen cases who are at high risk and low risk for obstructive sleep apnea in general surgery patients.</p> Osama Ahmed, Zahid Habib, Sheeraz Ur Rahman, Arshad Beg, Maira Shoaib, Asma Hirani, Abeer Hamidani Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Substantiation of Multinational Association for Supportive Care in Cancer (MASCC) Score in Risk Assessment of Febrile Neutropenic Patients in Hematological Disorders: A Regional Study from Pakistan <p><strong>Abstract: Background: </strong>The incidence of neutropenia in hematological malignancies comprises of huge burden of febrile neutropenia. Multinational Association of Supportive Care in Cancer (MASCC) risk index score is the most widely used model for forecast of complications.</p> <p><strong>Objective: </strong>The aim of this study was to determine diagnostic accuracy of MASCC scoring system in febrile neutropenia patients suffering from hematological disorders.</p> <p><strong>Materials &amp; Methods: </strong>Patients suffering from hematological disorders and presenting with febrile neutropenia were stratified into low and high risk groups according to MASSC score. The standard score range from 0 to 26 points; score of more than or equals to 21 were considered to be low risk and score of less than 21 was high-risk category. As an in-patient at National Institute of Blood Disease &amp; Bone Marrow Transplantation, they were followed over the course of illness for development of any serious medical condition until resolution of febrile neutropenia.</p> Qurratul Ain Rizvi, Aisha Jamal, Naveena Fatima, Munira Borhany, Uzma Zaidi, Tahir Sultan Shamsi Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 Trend of Anti-SARS-COV-2 Seropositivity in Karachi <p><strong>Abstract: Objective: </strong>This study aims to determine the trend of seropositivity of anti-SARS-CoV-2 antibodies (total including IgM, Ig G) in patients presenting at a private hospital in Karachi.</p> <p><strong>Materials &amp; Methods: </strong>A total of 2500 patients were included in the study. Informed consent was obtained and a questionnaire including patient’s age, gender, symptoms, history of traveling, contact with people who had travelled recently, contact with confirmed/suspected COVID-19 patient at home or work was filled. Samples were analyzed for anti-SARS-CoV-2 antibodies on Roche Cobase601.</p> Nayab Afzal, Naila Tariq, Danish Shakeel, Sadia Sultan Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000 What do the White Spots in the Second Part of Duodenum Tell Us? <p><strong>Abstract: Objective: </strong>The underlying conditions/diseases of scattered white spots in the duodenum are rather not very clear in the literature. We aimed to find out whether <em>Helicobacter pylori</em>, diabetes mellitus or inflammation has an impact on the presence of duodenal white spots.</p> <p><strong>Materials &amp; Methods: </strong>We included all patients who underwent endoscopy between the time-period 2007-2017 in the Endoscopy Unit of Cumhuriyet University and had scattered white spots in the duodenum. Our control group was formed by randomly selected patients who underwent endoscopy at the same time period in whom duodenal biopsy was taken. The demographic data of both the patient and the control group, the presence of diabetes, endoscopic and histological diagnoses, neutrophil lymphocyte ratio, thrombocyte lymphocyte ratio, mean platelet volume and erythrocyte distribution width were obtained from the computer system of the hospital in detail.</p> Ozge Kurtkulagi, Ozlem Yonem, Hatice Terzi, Engin Altinkaya, Ozgur Kurtkulagi Copyright (c) 2021 National Journal of Health Sciences Tue, 30 Mar 2021 00:00:00 +0000