Acute Promyelocytic Leukemia in Pediatric Population: A Rare Presentation

Authors

  • Rabiah Asghar Department of Pathology, Pakistan Institute of Medical Sciences Islamabad, Pakistan.
  • Javera Tariq Department of Pathology, Pakistan Institute of Medical Sciences Islamabad, Pakistan
  • Shahzad Ali Jiskani Department of Pathology, Pakistan Institute of Medical Sciences Islamabad, Pakistan.
  • Sundas Ali Department of Pathology, Pakistan Institute of Medical Sciences Islamabad, Pakistan.
  • Aneela Zafar Department of Pathology, Pakistan Institute of Medical Sciences Islamabad, Pakistan

Keywords:

Acute promyelocytic leukemia, Retinoic acid syndrome, All-Trans retinoic acid, FAB AML-M3, Sudan Black-B

Abstract

Abstract: Acute Promyelocytic Leukemia (APL) is a very uncommon type of acute myeloid leukemiacomprising less than 10% of pediatric population. Acute Promyelocytic leukemia is a neoplastic proliferation of abnormal promyelocytes in bone marrow, caused by cytogenetic abnormality t(15;17). Majority of patients (80%) have long term survival, and death occurs in approximately 10% of patients in early course of the disease; mainly because of hemorrhage. Hemorrhagic complications can be reduced by appropriate therapy if started timely, which ultimately reduces the risk of death. We report a case of 7 years old boy with complaints of fever off and on for past 06 months, bruises and swelling on left leg for 1 week, blood containing vomiting for 1day. He was diagnosed as APL on bone marrow biopsy.

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Published

2020-11-04

How to Cite

1.
Asghar R, Tariq J, Jiskani SA, Ali S, Zafar A. Acute Promyelocytic Leukemia in Pediatric Population: A Rare Presentation. Nat J Health Sci [Internet]. 2020Nov.4 [cited 2024Apr.26];5(2):83-5. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/13

Issue

Vol. 5 No. 2 (2020)

Section

Case Report