Deletion 7q Abnormality in a Childhood Pre B All: A Case Report and Review of Literature

Authors

  • Zainab Sharif Department of Pediatric Hematology, National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Pakistan.
  • Munira Borhany Department of Clinical Hematology, National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Pakistan.
  • Tahir Sultan Shamsi Department of Clinical Hematology, National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Pakistan.

Keywords:

Chromosome 7, Deletion 7q22-34, Tumor suppressor gene, Leukemogenesis, Cytogenetics

Abstract

Abstract: Aim: In childhood and adult acute myeloid leukemia and myelodysplastic syndrome chromosome 7 aberrations are not an uncommon finding. But in childhood acute lymphoblastic leukemia it is rarely seen. In this case we identified a rare cytogenetic aberration in a girl with Precursor B cell acute lymphoblastic leukemia. Method: Ten and a half year old girl presented with complaints of fever for two weeks and generalized body swelling for ten days. She was anemic, tachycardia with mild hepatosplenomegaly. She had raised TLC-67x109/L with 52% blasts. MLL gene and BCR-ABL were negative. Result: Our patient cytogenetic analysis showed deletion 7q22-34. Conclusion: Studies have shown that the long arm of 7q from 7q22-q36 has many important tumor suppressor genes located on it. Thus its deletion results in increased Leukemogenesis propensity. It will be interesting to find any interconnection between myeloid and lymphoid clones and chromosome 7 abnormalities.

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Published

2020-12-22

How to Cite

1.
Sharif Z, Borhany M, Shamsi TS. Deletion 7q Abnormality in a Childhood Pre B All: A Case Report and Review of Literature. Nat J Health Sci [Internet]. 2020Dec.22 [cited 2024May20];4(2):87-9. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/54

Issue

Section

Case Report

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