Tumefactive Multiple Sclerosis: A Mimicker of Intracranial Space-Occupying Lesions

Authors

  • Muhammad Sohail Ajmal Ghoauri Department of Neurology, Bahawal Victoria Hospital, Quaid-e-Azam Medical College, Bahawalpur, Pakistan.
  • Nauman Ismat Butt Department of Medicine & Allied, Azra Naheed Medial College, Superior University Lahore, Pakistan.
  • Fahad Qaisar Department of Medicine, Bahawal Victoria Hospital, Quaid-e-Azam Medical College, Bahawalpur, Pakistan.
  • Muhammad Bilal Rasheed Department of Medicine & Allied, Azra Naheed Medial College, Superior University Lahore, Pakistan.
  • Shoaib Luqman Department of Neurology, Bahawal Victoria Hospital, Quaid-e-Azam Medical College, Bahawalpur, Pakistan.
  • Sabir Ali Department of Neurology, Bahawal Victoria Hospital, Quaid-e-Azam Medical College, Bahawalpur, Pakistan.

Keywords:

Multiple sclerosis, Tumefactive lesions, Demylination, MRI scan, Oral steroids, Radiography

Abstract

Abstract: A chronic disease of CNS, Multiple sclerosis is characterized by inflammation and demyelination with axonal injury affecting upper motor neurons of brain or spinal cord. Tumefactive multiple sclerosis is a rare form of MS which mimics intracranial tumor-like space-occupying lesions on radiography. A 25-year old gentleman presented 2-month history of gradual onset difficulty in walking, slurring of speech and double vision. The patient had an ataxic gait accentuated by tandem walking with tendency to fall towards right and a negative Romberg’s sign. There was dysarthria and signs of cerebellar lesion present on the right side. Muscle tone was normal in upper limbs but increased (spasticity) in lower limbs bilaterally. Power was normal but deep tendon reflexes were exaggerated in all 4 limbs with bilateral up-going plantar reflex. MRI scan of the brain demonstrated tumour-like tumefactive lesions in the right cerebellum, right pons and the left subcortical region with no post-contrast enhancement of these lesions.  MRI of whole spine demonstrated subtle hyperintense signals in the cervical spine. He had a past history of transverse myelitis 2 years ago with full clinical recovery with oral steroids. He was diagnosed with Tumefactive Multiple Sclerosis and started on corticosteroid therapy resulting in dramatic improvement.

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Published

2024-03-11

How to Cite

1.
Ghoauri MSA, Butt NI, Qaisar F, Rasheed MB, Luqman S, Ali S. Tumefactive Multiple Sclerosis: A Mimicker of Intracranial Space-Occupying Lesions. Nat J Health Sci [Internet]. 2024Mar.11 [cited 2024Apr.13];9(1):57-60. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/536

Issue

Section

Case Report

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