Nephrotic Syndrome Secondary to Primary Membranoproliferative Glomerulonephritis in a 27 Years Old Nigerian Male

Authors

  • Peter K. Uduagbamen Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Clinical Sciences, Bowen University/Bowen University Teaching Hospital, Ogbomosho, Nigeria.
  • Gbemi H. Ano-Edward Division of Morbid Anatomy and Histopathology, Department of Pathology, Faculty of Clinical Sciences, Bowen University / Bowen University Teaching Hospital, Ogbomosho, Nigeria.
  • Sandra O. Idris Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Clinical Sciences, Bowen University / Bowen University Teaching Hospital, Ogbomosho, Nigeria.
  • Tochukwu P. Ogbonna Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Clinical Sciences, Bowen University / Bowen University Teaching Hospital, Ogbomosho, Nigeria.
  • Solomon Kadiri Nephrology Unit, Department of Internal Medicine, University College Hospital, Ibadan, Nigeria.
  • Ayodeji Arije Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Clinical Sciences, Bowen University / Bowen University Teaching Hospital, Ogbomosho, Nigeria.

Keywords:

Membranoproliferative, glomerulonephritis, Nephrotic syndrome, Kidney biopsy, Histology, Proteinuria, Hypercholesterolemia

Abstract

Abstract: Membranoproliferative glomerulonephritis (MPGN) is not a common cause of nephrotic syndrome (NS) in adults unlike in children. It is commonly steroid-resistant in adults unlike in children. Tissue diagnosis needed for effective management could be unavailable due to cost, particularly in resource poor settings. Patient was examined, had urine analysis, serum biochemistry assay, kidney scan and a kidney biopsy for histological diagnosis.

The patient had generalized oedema, with ascites, elevated blood pressure (156/90 mmHg) and massive proteinuria (4.6 g/day). The haemogram showed haematocrit of 32%, with absolute lymphocytosis (72%). Fasting lipids showed hypercholesterolemia (533 mg/dl), elevated LDL (274 mg/dl), low HDL (27 mg/dl) and hypertriglyceridemia (302 mg/dl). Ultrasound showed enlarged kidneys. Histological findings were mesangial hypercellularity, double-contour formation along the glomerular capillary wall (tram track appearance) and endocapillary proliferation. He was managed with intravenous methylprednisolone, (followed by gradually reducing oral doses), frusemide, atorvastatin, antibiotics and had daily weighing. He responded well to treatment. He was counselled on good compliance and has been on follow-up visits. His clinical and laboratory parameters have been normal.

Nephrotic syndrome from MPGN should be looked out for in adults presenting with NS and their treatment with steroids could be very beneficial.

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Published

2023-12-28

How to Cite

1.
Uduagbamen PK, Ano-Edward GH, Idris SO, Ogbonna TP, Kadiri S, Arije A. Nephrotic Syndrome Secondary to Primary Membranoproliferative Glomerulonephritis in a 27 Years Old Nigerian Male. Nat J Health Sci [Internet]. 2023Dec.28 [cited 2024Feb.21];8(4):212-5. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/496

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Section

Case Report

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