Sweat Gland Tumors – A Systematic Review on the Histopathology and Immunohistochemistry

Authors

  • Sana Khan Department of Medicine, Islamic International Medical College, Rawalpindi, Pakistan.
  • Khalid Mahmood Uddin Department of Neurology, Henry Ford Hospital, Detroit, USA.
  • Shamail Zia Department of Pathology, Jinnah Sindh Medical University, Karachi, Pakistan.
  • Cynthia Chizoba Esimoleze Department of Medicine, Faculty of Medicine and Health Sciences, Abia State University Uturu, Nigeria.
  • Sarah Khalid 5Department of Dermatology, Baqai Medical University, Karachi, Pakistan.
  • Farozaan Shamail Department of Pathology, Ziauddin Medical University, Karachi, Pakistan.
  • Fazail Zia Department of Pathology, Jinnah Sindh Medical University, Karachi, Pakistan.
  • Syed Jawwad Ali Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan.
  • Muhammad Ali Khan Department of Pathology, Jinnah Sindh Medical University, Karachi, Pakistan.

Abstract

Objective: The categorization of sweat gland tumors has been inconsistent over time. These tumors, having varying potential for
malignancy, may behave as indolent neoplasms while others can be highly metastatic. The characteristics of most of these tumors are
overlapping and the information of distinctive findings about these neoplasms is imperative. Traditionally, sweat gland tumors were classified
as eccrine and apocrine only but recently, this has been found that several sweat gland tumors may exhibit eccrine and apocrine types both.
Some tumors exhibit further complex features due to the existence of other differential appearances. This can be in the instance of apocrine
neoplasms because of the close embryological link between apocrine glands, hair follicles and sebaceous glands and they can be classified as
follicular and/or sebaceous tumors. Cutaneous adnexal neoplasms are a diagnostic challenge, especially for tumors with sweat gland
differentiation, due to a huge number of uncommon entities, designation of different terms to the identical tumor following to disagreement
about the taxonomy and nomenclature of such tumors. This review article provides updated information about various cancerous sweat gland
neoplasms with emphasis on recent conclusions for the diagnosis and generalized therapy of such neoplasms.

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Published

2022-06-30

How to Cite

1.
Khan S, Uddin KM, Zia S, Esimoleze CC, Khalid S, Shamail F, Zia F, Ali SJ, Khan MA. Sweat Gland Tumors – A Systematic Review on the Histopathology and Immunohistochemistry. Nat J Health Sci [Internet]. 2022Jun.30 [cited 2024Apr.26];7(2):85-9. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/315

Issue

Vol. 7 No. 2 (2022)

Section

Review Article

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