Immune Thrombocytopenia

Abstract

Immune thrombocytopenia (ITP) is characterized by immune mediated platelet destruction in the body. Autoantibodies are formed directed against platelet surface membrane glycoproteins; antibody coated platelets are removed from circulation by the macrophages of reticuloendothelial system in spleen, liver and other parts of the body [1]. When the rate of destruction of platelets exceeds the rate of platelet production in the bone marrow, platelet count starts to decline resulting in thrombocytopenia. The degree of thrombocytopenia may vary; this condition runs a relapsing and remitting course.