Drug-Drug Interaction between Non-Steroidal Anti-Inflammatory and Angiotensin Receptor Blocker


  • Mahreen Muzammil Department of Pharmacy Services, Aga Khan University Hospital, Karachi, Pakistan.
  • Syed Saad Hussain Pharmacy Department, Iqra University, Karachi, Pakistan.


Drug-drug interaction, Pharmacotherapy, Tertiary care hospital, Naproxen, Losartan, Clinical pharmacy


Abstract: In pharmacotherapy, factors such as mode of administration, dose, and contraindications play a significant part in determining the optimal pharmacotherapeutic strategy. A drug's ability to influence the safety or efficacy of another drug (drug-drug interaction) is another factor to consider when choosing the best pharmacotherapy [1]. When multiple medications are prescribed at the same time, they may interact [2]. Drug-drug interactions (DDIs) can have a variety of outcomes, and adverse DDIs might result in patient death or drug withdrawal. Drug interactions can alter the pharmacokinetics and/or pharmacodynamics of a drug which may leads to therapeutic failure or any adverse drug event. Co-administration of naproxen with losartan will decrease the action of losartan which is an anti-hypertensive agent leads to uncontrolled hypertension. NSAIDs inhibit prostaglandin thus antagonise effect of converting enzyme inhibitors. Losartan is angiotensin receptor blocker, whose natriuretic effects decreased by naproxen.




How to Cite

Muzammil M, Hussain SS. Drug-Drug Interaction between Non-Steroidal Anti-Inflammatory and Angiotensin Receptor Blocker. Nat J Health Sci [Internet]. 2022Mar.7 [cited 2022Jun.27];6(2):88-9. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/215



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