Drug-Drug Interaction between Non-Steroidal Anti-Inflammatory and Angiotensin Receptor Blocker

Authors

  • Mahreen Muzammil Department of Pharmacy Services, Aga Khan University Hospital, Karachi, Pakistan.
  • Syed Saad Hussain Pharmacy Department, Iqra University, Karachi, Pakistan.

Keywords:

Drug-drug interaction, Pharmacotherapy, Tertiary care hospital, Naproxen, Losartan, Clinical pharmacy

Abstract

Abstract: In pharmacotherapy, factors such as mode of administration, dose, and contraindications play a significant part in determining the optimal pharmacotherapeutic strategy. A drug's ability to influence the safety or efficacy of another drug (drug-drug interaction) is another factor to consider when choosing the best pharmacotherapy [1]. When multiple medications are prescribed at the same time, they may interact [2]. Drug-drug interactions (DDIs) can have a variety of outcomes, and adverse DDIs might result in patient death or drug withdrawal. Drug interactions can alter the pharmacokinetics and/or pharmacodynamics of a drug which may leads to therapeutic failure or any adverse drug event. Co-administration of naproxen with losartan will decrease the action of losartan which is an anti-hypertensive agent leads to uncontrolled hypertension. NSAIDs inhibit prostaglandin thus antagonise effect of converting enzyme inhibitors. Losartan is angiotensin receptor blocker, whose natriuretic effects decreased by naproxen.

Downloads

Published

2022-03-07

How to Cite

1.
Muzammil M, Hussain SS. Drug-Drug Interaction between Non-Steroidal Anti-Inflammatory and Angiotensin Receptor Blocker. Nat J Health Sci [Internet]. 2022Mar.7 [cited 2022Jun.27];6(2):88-9. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/215

Issue

Section

Case Report