Interim-Guidelines for COVID-19 Vaccination in Hematological Malignancies and Hematopoietic Stem Cell Transplant Recipients

Authors

  • Raheel Iftikhar Department of Clinical Hematology, Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Punjab, Pakistan.
  • Uzma Zaidi Department of Clinical Hematology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan.

Keywords:

COVID-19 vaccination, Hematological malignancies, Hematopoietic stem cell transplant, mRNA vaccine, Acute leukemia, Chemotherapy

Abstract

Abstract: Objective: Hematologic malignancies such as Acute Leukemias, Myelodysplastic Syndromes (MDS), Myeloproliferative
Neoplasms (MPNs), Lymphomas and Multiple Myeloma (MM) can be treated with chemotherapy, Hematopoietic Stem Cell Transplant (HSCT) or Chimeric Antigen Receptor T-cell (CAR-T) therapies with either a curative intent or to prolong survival. The hematologic malignancy itself or the anti-cancer therapies can result in long-term immunodeficiency; COVID-19 infection in this population is associated with a significantly higher risk of hospitalization and death [1].
Given lack of available data on COVID-19 vaccination from Pakistan, this guidance is based on the review of safety and efficacy of FDA and CDC approved vaccines for the prevention of COVID-19 disease and recommendations of European Society for Blood and Marrow Transplant (EBMT), American Society for Transplantation and Cellular Therapies (ASTCT) and British Society of Haematology (BSH) for the use of COVID vaccination in HSCT recipients and those with hematological malignancies. The American Society of Hematology (ASH), EBMT, ASTCT and BSH recommends the desired access to vaccines for this highly susceptible
group along with care takers, family members, and domestic& everyday contacts when vaccine supply is available.

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Published

2021-11-08

How to Cite

1.
Iftikhar R, Zaidi U. Interim-Guidelines for COVID-19 Vaccination in Hematological Malignancies and Hematopoietic Stem Cell Transplant Recipients. Nat J Health Sci [Internet]. 2021Nov.8 [cited 2022Dec.3];6(1):38-43. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/200

Issue

Section

Guidelines