Aberrant Expression of a T-Cell and a Monocytic Antigen in a Newly Diagnosed Precursor B-Cell Acute Lymphoblastic Leukaemia

Authors

  • Saima Siddiqui Department of Immunology, National institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan.
  • Madiha Saud Department of Immunology, National institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan.
  • Noman Ramzan Department of Immunology, National institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan.

Keywords:

Aberrant expression of antigens, CD5 and CD64 co-expression, Monocytic, Organomegal, Pre-B-ALL

Abstract

Abstract: Background: Aberrant expression of antigens/or loss of some antigens on leukemic cells is sometimes seen. Such expressions may or not affect prognosis of leukaemia. Aberrant co-expression of CD5 and CD64 on precursor B-cell ALL leukemic cells is found first time. Objective: To report a novel case of precursor B-cell ALL which co-expressed a T-cell lineage (CD5) and a monocytic lineage (CD64) antigens. Methods: Bone marrow immunophenotyping was performed using FACSCalibur (a four-color flowcytometer) and acute leukaemia panel of antibodies. Case Presentation: A 4-year old boy with circulating small sized blasts. Immunophenotyping data revealed expression of CD45, CD19, CD79a, TdT, CD34, CD10, CD5 and CD64 while absence of CD3, MPO, CD13, CD33, CD4, CD7 and CD8 antigens. Conclusion: A diagnosis of precursor B-cell ALL with aberrant CD5 and CD64 expression was made.

Downloads

Published

2020-12-30

How to Cite

1.
Siddiqui S, Saud M, Ramzan N. Aberrant Expression of a T-Cell and a Monocytic Antigen in a Newly Diagnosed Precursor B-Cell Acute Lymphoblastic Leukaemia . Nat J Health Sci [Internet]. 2020Dec.30 [cited 2024Apr.25];2(3):128-31. Available from: https://ojs.njhsciences.com/index.php/njhs/article/view/124

Issue

Vol. 2 No. 3 (2017)

Section

Case Report