@article{TAY_Özgen_Büyükkör_2022, title={Does Late Axial Spondyloarthropathy Diagnosis Cause Extra Anti-TNF Therapy?}, volume={7}, url={https://ojs.njhsciences.com/index.php/njhs/article/view/308}, abstractNote={<p>Introduction: Ankylosing Spondylitis (AS) is a chronic inflammatory rheumatic disease that mainly characterized by sacroiliac<br>joint and spine involvement. Although there is no clear evidence that any of these agent prevent the radiologic progression, anti-TNF drugs provide significant improvements in the disease activity score, functional index and quality of life.<br>In AS patients, knowledge of the factors that determine the need for anti-TNF treatment will be associated with fewer complication sand better treatment. The purpose of this study is to investigate the possible factors which willmark the transition to the anti-TNF therapy in AS patients.<br>Materials and Methods: This study was conducted in the Rheumatology division of the Internal medicine department of the Ondokuz Mayis<br>University of Medicine hospital between January 2012- June 2015. The study protocol was approved by the Ethics Committee of Ondokuz<br>Mayis University. A total of 165 patients, who were diagnosed as AS according to the ASAS classification criteria, were enrolled in this study.<br>There were 85 women (51.5%) and 80 men (48.5%), aged between 15-69. Patients were divided into two groups according to their use of<br>anti-TNF drug.<br>Results: A total of 165 Ax-SpA patients (85 women and 80 men) were included in the study. The mean age was 37.82±11.24 years. The mean<br>duration of the disease was 4.59±5.35 years. male gender, uveitis, delay in diagnosis, elevations in sedimentation CRP levels, increase in<br>disease activity and functional indexes such as BASDAI and BASFI scores shows the more frequent need for anti-TNF drug use.<br>Conclusion: In our study, patients who needed anti-TNF treatment had a longer time between symptom onset and diagnosis than patients who<br>did not hear. The delay in diagnosing these patients leads to a delay in treatment so that the focus of inflammation increases and these patients<br>need more anti-TNF as this window of opportunity escapes.</p>}, number={2}, journal={National Journal of Health Sciences}, author={TAY, Fatih and Özgen, Metin and Büyükkör, Mustafa}, year={2022}, month={Jun.}, pages={50-55} }